HIF 1α viral vector inhibits hippocampal neuronal apoptosis: The future of gene therapy

(Neural Regeneration Research) Hypoxia-inducible factor 1 attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxidative stress or hypoxia in cortical neurons. Professor Xiqing Chai and co-workers from Hebei Chemical and Pharmaceutical College, China constructed a recombinant adeno-associated virus vector expressing the human HIF-1α gene efficiently, and tested the assumption that rAAV-HIF-1α represses hippocampal neuronal apoptosis induced by amyloid-beta protein.